Transepithelial transport of putrescine across monolayers of the human intestinal epithelial cell line, Caco- 2
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منابع مشابه
Transepithelial transport of ambroxol hydrochloride across human intestinal Caco-2 cell monolayers.
This study aimed i) to characterize the transepithelial transport of the mucolytic agent ambroxol hydrochloride across the intestinal barrier, ii) to classify the ambroxol according to Biopharmaceutics Classification System (BCS) and iii) to predict ambroxol absorption in humans. Transport of ambroxol (100, 300 and 1000 micromol/l) was studied in a human colon carcinoma cell line Caco-2 in apic...
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The transport characteristics of a selective peripheral H1 receptor antagonist, ebastine, a substrate for cytochrome P450 3A4, and its three major metabolites, i.e., the hydroxy metabolite of ebastine (M-OH), the pharmacologically active metabolite carebastine (Car), and the desbutyrophenone metabolite (des-BP), were studied in cultured human intestinal Caco-2 cells expressing a drug efflux pum...
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Ulcerative colitis is a disease more commonly seen in nonsmokers. Because nicotine was postulated to be a beneficial component of tobacco smoke for ulcerative colitis, various formulations of nicotine have been developed to improve the local bioavailability within the gastrointestinal tissue. In the present study, to characterize the disposition of nicotine in the intestines, we investigated in...
متن کاملTransepithelial Transport of the in Human Intestinal Caco - 2 CellBioactive Tripeptide , Monolayers Val - Pro - Pro , Makoto
these tripeptides was studied by using monolayercultured human intestinaJ Caco-2 cells which express rnany enterocyte-Iike functions including the peptide transporter(PepTl)-mediated transport system. ValPro-Pro, an ACE-inhibitors peptide from fermented milk, was used as a model tripeptide. A significant amount of intact Val-Pro-Pro was transported across the Caco-2 cel) monolayer. This transpo...
متن کاملTransepithelial transport of rosmarinic acid in intestinal Caco-2 cell monolayers.
The absorption characteristics of rosmarinic acid (RA) were examined by measuring permeation across Caco-2 cell monolayers using an HPLC-electrochemical detector (ECD) fitted with a coulometric detection system. RA exhibited nonsaturable transport even at 30 mM, and the permeation at 5 mM in the apical-to-basolateral direction, J(ap-->bl), was 0.13 nmol/min/mg of protein. This permeation rate i...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2001
ISSN: 1007-9327
DOI: 10.3748/wjg.v7.i2.193